![]() Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from the European genome-wide association study in Asian populations. Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Structural MRI predictors of late-life cognition differ across African Americans, Hispanics, and Whites. Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank. Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits. Genome-wide association studies of brain imaging phenotypes in UK Biobank. Novel genetic loci associated with hippocampal volume. Identification of common variants associated with human hippocampal and intracranial volumes. ![]() Common variants at 12q14 and 12q24 are associated with hippocampal volume. Common genetic variants influence human subcortical brain structures. A pathophysiological framework of hippocampal dysfunction in ageing and disease. Progression from selective to general involvement of hippocampal subfields in schizophrenia. A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 65, 7–19 (2010). Biological studies of post-traumatic stress disorder. Plasticity of hippocampal subfield volume cornu ammonis 2+3 over the course of withdrawal in patients with alcohol dependence. Adult neurogenesis in the hippocampus: from stem. Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression. Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson’s disease. Risk factors for predicting progression from mild cognitive impairment to Alzheimer’s disease: a systematic review and meta-analysis of cohort studies. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease. The stressed hippocampus, synaptic plasticity and lost memories. Viewpoints: how the hippocampus contributes to memory, navigation and cognition. ![]() Place navigation impaired in rats with hippocampal lesions. Loss of recent memory after bilateral hippocampal lesions. ![]() These findings may provide insight into the genetic architectures of hippocampal and subfield volumes. These genetic variants are enriched for Wnt signaling and neuron differentiation and affect cognition, emotion and neuropsychiatric disorders. Cross-ancestry analysis improves the fine-mapping precision and the prediction performance of polygenic scores in under-represented populations. Common genetic variants have similar effects on hippocampal traits across ancestries, although ancestry-specific associations exist. We identify 339 variant–trait associations at P < 1.13 × 10 −9 for 44 hippocampal traits, including 23 new associations. Here we conduct cross-ancestry genome-wide association meta-analyses in 65,791 individuals for hippocampal volume and 38,977 for subfield volumes, including 7,009 individuals of East Asian ancestry. Genome-wide association studies on hippocampal and subfield volumes are mainly conducted in European populations however, other ancestral populations are under-represented. The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and its subfields differ in architecture and function. ![]() Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes ![]()
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